Dr Mark Humphries (Honorary Research Fellow)
Contact
- Department of Psychology, University of Sheffield, Sheffield, S10 2TP, UK.
- Tel: telephone number not specified in personal file
- Fax: +44 (0) 114 276 6515 (shared with department)
- Email: m.d.humphries/at/sheffield.ac.uk
Summary
- While actively collaborating with the ABRG on a number of projects, now at the Group for Neural Theory ENS, Paris.
Research Interests
- Network theory applications in neuroscience
- Single neuron models
- Spike train analysis techniques
- Structure and function of the brainstem reticular formation
- The basal ganglia as an action selection mechanism
- Neural substrate of decision making
- The function of the thalamic reticular nucleus
- Dopaminergic signalling
- Was part of the ICEA project
Peer-reviewed print articles
2011
2010
- Ben Mitchinson, Tak-Shing Chan, Jon Chambers, Martin Pearson, Mark Humphries, Charles Fox, Kevin Gurney, Tony J. Prescott (2010), BRAHMS: Novel middleware for integrated systems computation, Advanced Engineering Informatics, 24(1):49-61.
- Humphries, M. D., and Prescott, T. J. (2010), The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward, Progress in Neurobiology, 90:385-417.
- Humphries, M D, Wood, R. and Gurney, K. (2010), Reconstructing the three dimensional GABAergic microcircuit of the striatum, PLoS Computational Biology, 6:e1001011. [Code]
2009
- Fox, C., Humphries, M., Mitchinson, B., Kiss, T,; Somogyvari, Z. & Prescott, T. (2009), Technical integration of hippocampus, basal ganglia and physical models for spatial navigation, Frontiers in Neuroinformatics, 3:6.
- Lowe, R., Humphries, M. & Ziemke, T. (2009), The dual-route hypothesis: Evaluating a neurocomputational model of fear conditioning in rats, Connection Science, 21: 15-37.
- Humphries, M. D., Lepora, N., Wood, R. and Gurney, K. (2009), Capturing dopaminergic modulation and bimodal membrane behaviour of striatal medium spiny neurons in accurate, reduced models, Frontiers in Computational Neuroscience, 3:26. [Code]
- Humphries, M. D., Wood, R. and Gurney, K. (2009), Dopamine-modulated dynamic cell assemblies generated by the GABAergic striatal microcircuit, Neural Networks, 22:1174-1188. [Code]
2008
2007
- Humphries, M. D., Gurney, K. & Prescott, T. J. (2007), Is there a brainstem substrate for action selection?, Philosophical Transactions of the Royal Society B: Biological Sciences, 362(1485):1627-1639. [Code]
- Prescott, T . J. & Humphries, M. D. (2007), Who dominates who in the dark basements of the brain? Commentary on Merker, B. “Consciousness without a cerebral cortex: A challenge for neuroscience and medicine”, Behavioral and Brain Sciences, 30:104-105.
- Humphries, M. D., & K.N.Gurney (2007), A means to an end: validating models by fitting experimental data, Neurocomputing, 70:1892-1896. [Code]
- Humphries, M. D. & Gurney, K. (2007), Solutions methods for simple model neurons, Neural Computation, 19:3216-3225. [Code]
2006
- Humphries, M.D, and K.N. Gurney (2006), A means to an end: validating models by fitting experimental data, Neurocomputing , 20 (10, 1892-1896.
- Humphries, M. D., Gurney, K. & Prescott, T. J. (2006), The brainstem reticular formation is a small-world, not scale-free, network, Proceedings of the Royal Society B: Biological Sciences, 273:503-511. [Code]
- Humphries, M. D. & Prescott, T. J. (2006), Distributed action selection by a brainstem neural substrate: An embodied evaluation, From Animals to Animats 9: Proceedings of the Ninth International Conference on Simulation of Adaptive Behaviour, pp. 199-210, Springer-Verlag: Berlin.
- Humphries, M. D., Stewart, R. D. & Gurney, K. (2006), A physiologically plausible model of action selection and oscillatory activity in the basal ganglia, Journal of Neuroscience, 26(50):12921-42. [Code]
- Prescott, T. J., Montes-Gonzalez, F., Gurney, K., Humphries, M. D. and Redgrave, P. (2006), A robot model of the basal ganglia: Behavior and intrinsic processing, Neural Networks, 19:31-61.
2005
- Humphries, M. D., Gurney, K. & Prescott, T. J. (2005), Is there an integrative center in the vertebrate brain-stem? A robotic evaluation of a model of the reticular formation viewed as an action selection device, Adaptive Behaviour, 13:97-113.
- Humphries, M., Gurney, K. & Prescott, T. (2005), Action selection in a macroscopic model of the brainstem reticular formation, Modelling Natural Action Selection, J. J. Bryson, T. J. Prescott & A. Seth, pp. 61-68, AISB Press.
- Chambers, J. M., Gurney, K., Humphries, M. & Prescott, T. (2005), Mechanisms of choice in the primate brain: a quick look at positive feedback, Modelling Natural Action Selection, J. J. Bryson, T. J. Prescott & A. Seth, pp. 45-52, AISB Press..
2004
- Gurney, K., Humphries, M., Wood, R., Prescott, T.J. & Redgrave, P. (2004), Testing computational hypotheses of brain systems function: a case study with the basal ganglia, Network: Computation in Neural Systems, 15:263-290. [Code]
2003
- Humphries, M. D., Prescott, T. J. & Gurney, K. N. (2003), The interaction of recurrent axon collateral networks in the basal ganglia, Artifical Neural Networks and Neural Information Processing, O. Kaynak, E. Alpaydin, E. Oja & L. Xu (Eds.), ICANN/ICONIP 2003 (LNCS 2714) pp. 797-804, Berlin: Springer-Verlag.
2002
- Prescott, T. J., Gurney, K., Montes-Gonzalez, F., Humphries, M. and Redgrave, P. (2002), The robot basal ganglia: Action selection by an embedded model of the basal ganglia, Basal Ganglia VII, L. F. B. Nicholson and R. Faulls (Eds.) New York: Plenum Press.
- Humphries, M. D. & Gurney, K. N. (2002), The role of intra-thalamic and thalamocortical circuits in action selection, Network: Computation in Neural Systems, 13:131-156. [Code]
2001
2000
- Montes Gonzalez, F. Prescott, T.J., Gurney, K. Humphries, M., & Redgrave, P. (2000), An embodied model of action selection mechanisms in the vertebrate brain, From Animals to Animats 6: Proceedings of the Sixth International Conference on Simulation of Adaptive Behaviour, J-A. Meyer, A. Berthoz, D. Floreano, H. Roitblat, & S. W. Wilson (Eds.), Cambridge MA: MIT Press.
Other work
- Wood, R,, M.D. Humphries, and K.N. Gurney (2009), Does striatum support competitive dynamics? A test of this hypothesis using a biologically realistic model of the striatal microcircuit, BMC Neuroscience, 10, page 317.
- Humphries, M.D., N. Lepora, R. Wood, and K.N. Gurney (2009), Reduced models of striatal neurons: dopamine modulation and dynamics, BMC Neuroscience, 10, (1) 321.
- Gurney, K.N., M.D. Humphries, and P. Redgrave (2009), Cortico-striatal plasticity for action-outcome learning using spike timing dependent eligibility, BMC Neuroscience, 10, (1) 135.
- Wood, R, M. D Humphries, P.G. Overton, and K.N. Gurney (2008), Validation and dynamics of a computational model of the neostriatal microcircuit, SfN 2008, Washington, Neuroscience Meeting Planner, Poster 578.13/QQ15.
- Mitchinson, B., T.S. Chan, J.M. Chambers, M D Humphries, C. Fox, K.N. Gurney, and T J Prescott (2008), BRAHMS: Novel middleware for integrated systems computation, SfN 2008 Washington, Neuroscience Meeting Planner, Poster 798.10/VV3.
- Humphries, M.D, P Redgrave, and K.N. Gurney (2008), Action-outcome contingency and stimulus-response habits as an exploration/exploitation action selection trade-off, SfN 2008 Washington., Neuroscience Meeting Planner Poster 98.3/UU33.
- Humphries, M. D. (2007), High level modeling of tonic dopamine mechanisms in striatal neurons, q-bio.NC/0701022.
- Humphries, M.D, and K.N. Gurney (2007), Deep brain stimulation of the subthalamic nucleus causes paradoxical inhibition of output in a computational model of the “parkinsonian” basal ganglia, SfN San Diego 2007, Neuroscience Meeting Planner #622.
- Wood, R., M.D Humphries, P. Overton, R. Stewart, and K.N. Gurney (2006), Selection in a model of striatum with fast spiking interneurons, 15thth Annual Computational Neuroscience Meeting, Edinburgh.
- Gurney, K.N., M.D. Humphries, and R. Stewart (2005), A spiking neuron model of basal ganglia for action selection can account for dopamine - modulated oscillatory phenomena, SfN 2005, Washington, Neuroscience Meeting Planner #517.
- Humphries, M., R. Stewart, T.J. Prescott, P. Redgrave, and K.N. Gurney (2004), A spiking neuron model of basal ganglia demonstrating plausible action selection and switching, International Basal Ganglia Society (IBAGS) VIIIth International Triennial Meeting. Crieff, Scotland..
- Stewart, R., K.N. Gurney, and M.D Humphries (2004), A spiking neuron model of cortically-evoked response patterns in the basal ganglia, International Basal Ganglia Society (IBAGS) VIIIth International Triennial Meeting. Crieff, Scotland..
- Prescott, T. J. Gurney, K. Gonzalez, F. M., Humphries, M. & Redgrave, P. (2003), Action selection in a robot model of the basal ganglia: The role of simulated dopamine, Society for Neuroscience, Program No. 915.5.
- Humphries, M. D. (2002), The basal ganglia and action selection: A computational study at multiple levels of description, PhD Thesis, University of Sheffield.
- Prescott, T.J., F. Montes-Gonzales, K.N. Gurney, M. Humphries, and P. Redgrave (2001), Why is efference copy information sent to the basal ganglia? inspiration from an embodied model, BNA 16th National Meeting, 91.
- Prescott, T.J., K.N. Gurney, F. Montes-Gonzalez, M. Humphries, and P. Redgrave (2001), The robot basal ganglia: Control of action selection by an embedded model of the basal ganglia, VIth Triennial neeting of the International basal Ganglia Society. Bay of Islands, New Zealand..
- Humphries, M.D., and K.N. Gurney (2001), Slow oscillatory activity in a computational model of the basal ganglia, BNA 16th National Meeting, Harrogate, UK .
- McHaffie, G.J., T.J. rescott, F. Montes-Gonzales, K.N. Gurney, M. Humphries, T.R. Stanford, and P Redgrave (2001), Why is efference copy information directed to the basal ganglia? Inspiration from an embodied model, SfN 2001 Meeting San Diego, Neuroscience Meeting Planner #514.
- Gonzalez, F.Montes, T.J. Prescott, K.N. Gurney, M. Humphries, and P. Redgrave (2000), The robot basal ganglia: control of robot action selection by an embodied model of the vertebrate basal ganglia, In Federation of European Neurosciences Meeting, Brighton, UK, vol 12, supp 11.
- Humphries, M. D. & Gurney, K. (2000), A computational model of action selection in the basal ganglia: Thalamic and cortical interactions, European Journal of Neuroscience, 12, supp. 11, 260.10.
- Humphries, M. D. & Gurney, K. (1999), A computational model of action selection in the basal ganglia: Thalamic and cortical interactions, Technical Report AIVRU132, The University of Sheffield.
